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CVS is a rare

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diagnosis with distinctive features in adults. The involvement of group I mGlu

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receptors in anxiety and depression has also been wellbutrin abdominal pain cycles typically began without warning, and fewer than one-third of the subjects reported a prodrome

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or potential trigger event, such as menstrual periods, pregnancy, or large meals. In view of

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the recent discovery of anxiolytic- or antidepressant-like effects of acute injections of 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a selective and brain penetrable mGlu5 receptor antagonist, we designed the present study to examine anxiolytic- and/or antidepressant-like effects of multiple administrations of this drug. The antidepressant-like

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effect was estimated using the rat olfactory bulbectomy model of depression. Cyclic vomiting syndrome (CVS) has been described infrequently in adults, and treatment in both children and adults remains

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unsatisfactory. Cyclic vomiting syndrome in adults. Symptoms in CVS began at age 35 yr (range 14-73 yr); the average episode length was 6 days (range 1-21 days) and

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the symptom-free interval averaged 3.1 months (range 0.5-6 months). The anxiolytic-like effects of MPEP were evaluated

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in rats using the conflict drinking test. MPEP given once daily at a dose of 10 mg/kg, restored the learning deficit of bulbectomized rats after 14 days of treatment, remaining without any effect in the sham-operated animals. Tricyclic antidepressant therapy was associated with complete remission in 17.6% and partial response

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in 58.8%, but was less effective than for functional nausea and vomiting (p 0.02). The results indicate that the prolonged blockade of mGlu5 receptors exerts anxiolytic- and antidepressant-like effects in rats. Clinical data were examined from 17 adult patients with CVS seen over a 10-yr period, each having been treated with a tricyclic antidepressant. Sleep was seemingly beneficial in 23.5%. We report clinical features of a group of adults with CVS and anecdotal outcome from open-label treatment with tricyclic antidepressants, medications that have some efficacy in other unexplained gastrointestinal disorders. No tolerance to anxiolytic-like action occurs. Outpatient records were revie clinical outcome was extracted using a priori

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criteria, and findings were compared with 37 patients having usual functional nausea and vomiting who also received tricyclic antidepressant therapy. In open-label, uncontrolled use, tricyclic antidepressants appear beneficial for some subjects but are less effective in CVS than in chronic, persistent functional nausea and vomiting. Clinical features and response to tricyclic antidepressants.OBJECTIVE. N-methyl-D-aspartic acid (NMDA)-induced convulsions in mice were not affected by a single injection of MPEP (30 mg/kg) indicating that at this

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dose MPEP did not block NMDA receptors.

The previously mentioned results further indicate that antagonists of group I mGlu receptors may play a role in the therapy of both anxiety and depression.. Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats.Several lines of evidence suggest a crucial involvement of glutamate in the mechanism of action of anxiolytic and antidepressant drugs.